Past And Present For The Future Of Research On Transcendence In Education And Values

As the world becomes more diverse, discussions surrounding religion and spiritual beliefs and their roles in educational systems have acquired significant relevance. There is an ongoing debate on whether the study of religion in education can serve as a means of transmitting common values within society and bridging different perspectives on reality. This topic stands to benefit from scientific analysis, particularly in exploring the relationship between religion, education, and values, and their impact on various aspects of well-being, including mental and physical health. Furthermore, it is essential to recognize the social and interpersonal dimensions of religion and spirituality. Moreover, identity, diversity, and culture play significant roles in this area of research. Therefore, future studies should aim for a comprehensive understanding of how religion and spiritual beliefs affect both individuals and society as a whole. This understanding is crucial to establish inclusive educational environments that promote a sense of belonging and foster respect for diverse beliefs and practices

Silenced Voices: Effects of Gender-Based Violence on the Physical Health and Well-Being of Sons and Daughters

In recent years, it has been observed that gender-based violence within the family context affects all members, especially children. Minors are often in two main situations: either they are victims of violence alongside their mother, or they witness it in some other way. Numerous studies (Aravena, et al., 2023; Román-Gálvez, et al., 2021; Maciel, et. al., 2019; Carlson, et al., 2020; Tenkorang, 2023) have documented the high prevalence of violence against women and children. Astorga 2022, points out that these experiences have effects on the individual, family, and societal level, emphasizing the need to focus on psychotherapeutic and psychosocial attention not only on mothers but also on children, recognizing the multi-generational dimension of this phenomenon. This study aims to review the current state of research on the physical and psychosocial repercussions on minors who have witnessed parental conflicts and reflect on new implications for research and intervention in this field

Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma.

Mice in which lung epithelial cells can be induced to express an oncogenic Kras(G12D) develop lung adenocarcinomas in a manner analogous to humans. A myriad of genetic changes accompany lung adenocarcinomas, many of which are poorly understood. To get a comprehensive understanding of both the transcriptional and post-transcriptional changes that accompany lung adenocarcinomas, we took an omics approach in profiling both the coding genes and the non-coding small RNAs in an induced mouse model of lung adenocarcinoma. RNAseq transcriptome analysis of Kras(G12D) tumors from F1 hybrid mice revealed features specific to tumor samples. This includes the repression of a network of GTPase-related genes (Prkg1, Gnao1 and Rgs9) in tumor samples and an enrichment of Apobec1-mediated cytosine to uridine RNA editing. Furthermore, analysis of known single-nucleotide polymorphisms revealed not only a change in expression of Cd22 but also that its expression became allele specific in tumors. The most salient finding, however, came from small RNA sequencing of the tumor samples, which revealed that a cluster of ∼53 microRNAs and mRNAs at the Dlk1-Dio3 locus on mouse chromosome 12qF1 was markedly and consistently increased in tumors. Activation of this locus occurred specifically in sorted tumor-originating cancer cells. Interestingly, the 12qF1 RNAs were repressed in cultured Kras(G12D) tumor cells but reactivated when transplanted in vivo. These microRNAs have been implicated in stem cell pleuripotency and proteins targeted by these microRNAs are involved in key pathways in cancer as well as embryogenesis. Taken together, our results strongly imply that these microRNAs represent key targets in unraveling the mechanism of lung oncogenesis

Data Security Enhancement in 4G Vehicular Networks Based on Reinforcement Learning for Satellite Edge Computing

The vehicular network provides the dedicated short-range communication (DSRC) with IEEE 802.11p standard. The VANET model comprises of cellular vehicle-to-everything communication with wireless communication technology. Vehicular Edge Computing exhibits the promising technology to provide promising Intelligent Transport System Services. Smart application and urban computing. Satellite edge computing model is adopted in vehicular networks to provide services to the VANET communication for the management of computational resources for the end-users to provide access to low latency services for maximal execution of service. The satellite edge computing model implemented with the 4G vehicular communication network model subjected to data security issues. This paper presented a Route Computation Deep Learning Model (RCDL) to improve security in VANET communication with 4G technology. The RCDL model uses the route establishment model with the optimal route selection. The compute route is transmitted with the cryptographic scheme model for the selection of optimal route identified from the satellite edge computing model. The proposed RCDL scheme uses the deep learning-based reinforcement learning scheme for the attack prevention in the VANET environment employed with the 4G technology communication model. The simulation results expressed that proposed RCDL model achieves the higher PDR value of 98% which is ~6% higher than the existing model. The estimation of end-to-end delay is minimal for the RCDL scheme and improves the VANET communication

Actualización diagnóstica y terapéutica del síndrome metabólico.

El síndrome metabólico se define como la asociación de problemas de salud que pueden aparecer de forma simultánea o secuencial en un individuo, causados por la combinación de factores genéticos y ambientales asociados al estilo de vida en los que la resistencia a la insulina se considera el componente patogénico fundamental. La presencia de síndrome metabólico se relaciona con un incremento significativo de riesgo de diabetes, enfermedad coronaria y cerebrovascular, con disminución de la supervivencia, por el incremento unas 5 veces en la mortalidad cardiovascular. Con la presente revisión pretendemos actualizar los conocimientos que sobre dicho síndrome existen, y contar con un material bibliográfico de consulta docente para profesores y estudiantes de medicina. El método de investigación científica utilizado consistió en la revisión documental. Se enfatizó en la importancia de identificar y tratar oportunamente las morbilidades presentes en estos pacientes como estrategia en la prevención de enfermedades cardiovasculares

The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog

Chronic spinal cord dysfunction occurs in dogs as a consequence of diverse aetiologies, including long-standing spinal cord compression and insidious neurodegenerative conditions. One such neurodegenerative condition is canine degenerative myelopathy (DM), which clinically is a challenge to differentiate from other chronic spinal cord conditions. Although the clinical diagnosis of DM can be strengthened by the identification of the Sod1 mutations that are observed in affected dogs, genetic analysis alone is insufficient to provide a definitive diagnosis. There is a requirement to identify biomarkers that can differentiate conditions with a similar clinical presentation, thus facilitating patient diagnostic and management strategies. A comparison of the cerebrospinal fluid (CSF) protein gel electrophoresis profile between idiopathic epilepsy (IE) and DM identified a protein band that was more prominent in DM. This band was subsequently found to contain a multifunctional protein clusterin (apolipoprotein J) that is protective against endoplasmic reticulum (ER) stress-mediated apoptosis, oxidative stress, and also serves as an extracellular chaperone influencing protein aggregation. Western blot analysis of CSF clusterin confirmed elevated levels in DM compared to IE (p < 0.05). Analysis of spinal cord tissue from DM and control material found that clusterin expression was evident in neurons and that the clusterin mRNA levels from tissue extracts were elevated in DM compared to the control. The plasma clusterin levels was comparable between these groups. However, a comparison of clusterin CSF levels in a number of neurological conditions found that clusterin was elevated in both DM and chronic intervertebral disc disease (cIVDD) but not in meningoencephalitis and IE. These findings indicate that clusterin may potentially serve as a marker for chronic spinal cord disease in the dog; however, additional markers are required to differentiate DM from a concurrent condition such as cIVDD

Monitorización de la temperatura esofágica vs. rectal durante la colecistectomía laparoscópica

Se realiza un estudio descriptivo en 40 pacientes tratados quirúrgicamente por colecistectomía laparoscópica en el Hospital Clínico Quirúrgico “Hermanos Ameijeiras” en el período de noviembre-diciembre, 1996, con el propósito de evaluar la precisión de la temperatura esofágica versus rectal en el control de la temperatura corporal central intraoperatoria. Se comprueba un descenso de la temperatura rectal hasta 35oC,  como promedio (1-15oC de su valor inicial). Esta disminución ocurre de forma progresiva en los primeros 30 minutos después de la inducción de la anestesia, con estabilidad posterior en el valor inferior, hasta la culminación del acto anestésico-quirúrgico. La temperatura corporal, tomada desde el tercio inferior del esófago, también mostró un descenso progresivo en los primeros 30 minutos con igual comportamiento en el tiempo que la rectal, pero hasta valores de 34o C (2-2,5o C del valor primario), como promedio, al culminar el proceder. Se concluye que ambos métodos demostraron ser sensibles para el control de las variaciones de la temperatura corporal central durante la colecistectomía laparoscópica con los valores obtenidos desde el tercio distal del esófago como más específicos, como expresión de las variaciones centrales de la temperatura corporal

Female heterozygotes for the hypomorphic R40H mutation can have ornithine transcarbamylase deficiency and present in early adolescence: a case report and review of the literature

<p>Abstract</p> <p>Introduction</p> <p>Ornithine transcarbamylase deficiency is the most common hereditary urea cycle defect. It is inherited in an X-linked manner and classically presents in neonates with encephalopathy and hyperammonemia in males. Females and males with hypomorphic mutations present later, sometimes in adulthood, with episodes that are frequently fatal.</p> <p>Case presentation</p> <p>A 13-year-old Caucasian girl presented with progressive encephalopathy, hyperammonemic coma and lactic acidosis. She had a history of intermittent regular episodes of nausea and vomiting from seven years of age, previously diagnosed as abdominal migraines. At presentation she was hyperammonemic (ammonia 477 μmol/L) with no other biochemical indicators of hepatic dysfunction or damage and had grossly elevated urinary orotate (orotate/creatinine ratio 1.866 μmol/mmol creatinine, reference range <500 μmol/mmol creatinine) highly suggestive of ornithine transcarbamylase deficiency. She was treated with intravenous sodium benzoate and arginine and made a rapid full recovery. She was discharged on a protein-restricted diet. She has not required ongoing treatment with arginine, and baseline ammonia and serum amino acid concentrations are within normal ranges. She has had one further episode of hyperammonemia associated with intercurrent infection after one year of follow up. An R40H (c.119G>A) mutation was identified in the ornithine transcarbamylase gene (<it>OTC</it>) in our patient confirming the first symptomatic female shown heterozygous for the R40H mutation. A review of the literature and correspondence with authors of patients with the R40H mutation identified one other symptomatic female patient who died of hyperammonemic coma in her late teens.</p> <p>Conclusions</p> <p>This report expands the clinical spectrum of presentation of ornithine transcarbamylase deficiency to female heterozygotes for the hypomorphic R40H <it>OTC </it>mutation. Although this mutation is usually associated with a mild phenotype, females with this mutation can present with acute decompensation, which can be fatal. Ornithine transcarbamylase deficiency should be considered in the differential diagnosis of unexplained acute confusion, even without a suggestive family history.</p

Arginine deprivation alters microglia polarity and synergises with radiation to eradicate non arginine auxotrophic glioblastoma tumors

New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the efficacy of radiotherapy for GBM is strikingly potentiated by concomitant therapy with the arginine depleting agent ADI-PEG20 in a non-arginine auxotrophic cellular background (Arginine Succinate Synthetase 1 positive). Moreover, this combination led to durable and complete radiological and pathological response with extended disease-free survival in an orthotopic immune competent model of GBM with no significant toxicity. ADI-PEG20 not only enhances the cellular sensitivity of Arginine succinate synthetase 1 positive GBM to ionising radiation by elevated production of nitric oxide (NO) and hence generation of cytotoxic peroxynitrites, but also promotes glioma-associated macrophages/microglia infiltration into tumors and turns their classical anti-inflammatory (pro-tumor) phenotype into a pro-inflammatory (anti-tumor) phenotype. Our results provide an effective, well-tolerated and simple strategy to improve GBM treatment which merits consideration for early evaluation in clinical trials